Stabletrans-Isomers of Bis(acetato)-triethylenetetramine-cobalt(III) and Bis(propionato)-triethylenetetramine-cobalt(III) Complexes
نویسندگان
چکیده
منابع مشابه
Complex N-acetylation of triethylenetetramine.
Triethylenetetramine (TETA) is an efficient copper chelator that has versatile clinical potential. We have recently shown that spermidine/spermine-N(1)-acetyltransferase (SSAT1), the key polyamine catabolic enzyme, acetylates TETA in vitro. Here, we studied the metabolism of TETA in three different mouse lines: syngenic, SSAT1-overexpressing, and SSAT1-deficient (SSAT1-KO) mice. The mice were s...
متن کاملTriethylenetetramine pharmacology and its clinical applications.
Triethylenetetramine (TETA), a Cu(II)-selective chelator, is commonly used for the treatment of Wilson's disease. Recently, it has been shown that TETA can be used in the treatment of cancer because it possesses telomerase inhibiting and anti-angiogenesis properties. Although TETA has been used in the treatment of Wilson's disease for decades, a comprehensive review on TETA pharmacology does no...
متن کاملTriethylenetetramine penta- and hexa-acetamide ligands and their ytterbium complexes as paraCEST contrast agents for MRI.
The ligand triethylenetetramine-N,N,N',N'',N''',N'''-hexaacetamide (ttham) was synthesized with the aim of forming lanthanide complexes suitable as contrast agents for magnetic resonance imaging applications utilizing the chemical exchange-dependent saturation transfer (CEST) effect. It was designed to exclude water molecules from the first coordination sphere and provide a high number of CEST ...
متن کاملPyrite Passivation by Triethylenetetramine: An Electrochemical Study
The potential of triethylenetetramine (TETA) to inhibit the oxidation of pyrite in H(2)SO(4) solution had been investigated by using the open-circuit potential (OCP), cyclic voltammetry (CV), potentiodynamic polarization, and electrochemical impedance (EIS), respectively. Experimental results indicate that TETA is an efficient coating agent in preventing the oxidation of pyrite and that the inh...
متن کاملSolid state stability and solubility of triethylenetetramine dihydrochloride.
The API triethylenetetramine dihydrochloride used as an alternative treatment of Wilson's disease is sensitive to water and it exhibits polymorphism. As this may become an issue for the drug formulation, the physical stability has been studied by differential scanning calorimetry, high-pressure thermal analysis, dynamic vapor sorption, and X-ray diffraction as a function of temperature. In addi...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1966
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.39.197